Polymorphisms of Calgranulin Genes and Ischemic Stroke in a Chinese Population.

ABSTRACT:

Background

The S100/calgranulin gene appears to modulate neuroinflammation following cerebral ischemia and could be a valuable biomarker for stroke prognosis, according to growing research. This study aimed at evaluating the correlation between calgranulin gene variants and susceptibility to ischemic stroke (IS) in the Southern Chinese population.

Methods

Using an enhanced multi-temperature ligase detection reaction genotyping, 310 IS patients and 324 age-matched healthy controls were genotyped to identify five calgranulin gene variants.

Results

According to the obtained results, the S100A8 rs3795391, rs3806232, and S100A12 rs2916191 variants were linked to a higher risk of IS, while the S100A9 rs3014866 variant was associated with a lower risk of IS. Moreover, the T-

SUBMITTER: Chen L 

PROVIDER: S-EPMC9191198 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature