Dysregulated ligand-receptor interactions from single-cell transcriptomics.

ABSTRACT:

Motivation

Intracellular communication is crucial to many biological processes, such as differentiation, development, homeostasis and inflammation. Single-cell transcriptomics provides an unprecedented opportunity for studying cell-cell communications mediated by ligand-receptor interactions. Although computational methods have been developed to infer cell type-specific ligand-receptor interactions from one single-cell transcriptomics profile, there is lack of approaches considering ligand and receptor simultaneously to identifying dysregulated interactions across conditions from multiple single-cell profiles.

Results

We developed scLR, a statistical method for examining dysregulated ligand-receptor interactions between two conditions. scLR models the distribution of the pro

SUBMITTER: Liu Q 

PROVIDER: S-EPMC9191214 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature