Transcriptomic analyses of black women in neighborhoods with high levels of violence.

ABSTRACT: Chronic stress threatens an individual's capacity to maintain psychological and physiological homeostasis, but the molecular processes underlying the biological embedding of these experiences are not well understood. This is particularly true for marginalized groups, presenting a fundamental challenge to decreasing racial, economic, and gender-based health disparities. Physical and social environments influence genome function, including the transcriptional activity of core stress responsive genes. We studied the relationship between social experiences that are associated with systemic inequality (e.g., racial segregation, poverty, and neighborhood violence) and blood cell (leukocytes) gene expression, focusing on the activation of transcription factors (TF) critical to stress response pat

SUBMITTER: Lee MJ 

PROVIDER: S-EPMC9191231 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature