Irritable bowel syndrome is strongly associated with the primary and idiopathic mast cell disorders.

ABSTRACT:

Background

Mounting evidence supports a mechanistic association between irritable bowel syndrome (IBS) symptoms and mast cell hyperactivity. Yet, association between IBS and mast cell disorders (MCDs) has not been studied. We examined this association using two large databases and verified with manual chart review.

Methods

The IBM Watson Health Explorys database (Somers, NY), an aggregate of electronic health record (EHR) data from over two dozen US healthcare systems, and Epic's SlicerDicer tool, a self-service tool containing de-identified data from the Epic EHR, were used to identify patients with IBS and MCDs. Patients with organic gastrointestinal disease or diseases associated with secondary mast cell hyperproliferation were excluded. Results were verified with manual

SUBMITTER: Kurin M 

PROVIDER: S-EPMC9191257 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature