Genetic diversity of Plasmodium vivax reticulocyte binding protein 2b in global parasite populations.

ABSTRACT:

Background

Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) plays a critical role in parasite invasion of reticulocytes by binding the transferrin receptor 1. PvRBP2b is a vaccine candidate based on the negative correlation between antibody titers against PvRBP2b recombinant proteins and parasitemia and risk of vivax malaria. The aim of this study was to analyze the genetic diversity of the PvRBP2b gene in the global P. vivax populations.

Methods

Near full-length PvRBP2b nucleotide sequences (190-8349 bp) were obtained from 88 P. vivax isolates collected from the China-Myanmar border (n = 44) and Thailand (n = 44). An additional 224 PvRBP2b sequences were retrieved from genome sequences from parasite populations worldwide. The genetic diversity, neutral selection,

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9191549 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature