Engineering nonphotosynthetic carbon fixation for production of bioplastics by methanogenic archaea.

ABSTRACT: The conversion of CO2 to value-added products allows both capture and recycling of greenhouse gas emissions. While plants and other photosynthetic organisms play a key role in closing the global carbon cycle, their dependence on light to drive carbon fixation can be limiting for industrial chemical synthesis. Methanogenic archaea provide an alternative platform as an autotrophic microbial species capable of non-photosynthetic CO2 fixation, providing a potential route to engineered microbial fermentation to synthesize chemicals from CO2 without the need for light irradiation. One major challenge in this goal is to connect upstream carbon-fixation pathways with downstream biosynthetic pathways, given the distinct differences in metabolism between archaea and typical heterotrophs. We engineer

SUBMITTER: Thevasundaram K 

PROVIDER: S-EPMC9191640 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature