Dynamic intracellular exchange of nanomaterials' protein corona perturbs proteostasis and remodels cell metabolism.

ABSTRACT: The nanomaterial–protein “corona” is a dynamic entity providing a synthetic–natural interface mediating cellular uptake and subcellular distribution of nanomaterials in biological systems. As nanomaterials are central to the safe-by-design of future nanomedicines and the practice of nanosafety, understanding and delineating the biological and toxicological signatures of the ubiquitous nanomaterial–protein corona are precursors to the continued development of nano–bio science and engineering. However, despite well over a decade of extensive research, the dynamics of intracellular release or exchange of the blood protein corona from nanomaterials following their cellular internalization remains unclear, and the biological footprints of the nanoparticle–protein corona traversing cellular comp

SUBMITTER: Cai R 

PROVIDER: S-EPMC9191665 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature