A multi-omics analysis for the prediction of neurocognitive disorders risk among the elderly in Macao.

ABSTRACT:

Background

Due to the increasing ageing population, neurocognitive disorders (NCDs) have been a global public health issue, and its prevention and early diagnosis are crucial. Our previous study demonstrated that there is a significant correlation between specific populations and NCDs, but the biological characteristics of the vulnerable group predispose to NCDs are unclear. The purpose of this study is to investigate the predictors for the vulnerable group by a multi-omics analysis.

Methods

Multi-omics approaches, including metagenomics, metabolomic and proteomic, were used to detect gut microbiota, faecal metabolites and urine exosome of 8 normal controls and 13 vulnerable elders after a rigorous screening of 400 elders in Macao. The multi-omics data were analysed using R

SUBMITTER: Han Y 

PROVIDER: S-EPMC9191869 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature