Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary.

ABSTRACT: Zebrafish are an established research organism that has made many contributions to our understanding of vertebrate tissue and organ development, yet there are still significant gaps in our understanding of the genes that regulate gonad development, sex, and reproduction. Unlike the development of many organs, such as the brain and heart that form during the first few days of development, zebrafish gonads do not begin to form until the larval stage (≥5 days post-fertilization). Thus, forward genetic screens have identified very few genes required for gonad development. In addition, bulk RNA-sequencing studies that identify genes expressed in the gonads do not have the resolution necessary to define minor cell populations that may play significant roles in the development and function of the

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9191896 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature