Clinical autism subscales have common genetic liabilities that are heritable, pleiotropic, and generalizable to the general population.

ABSTRACT: The complexity of autism's phenotypic spectra is well-known, yet most genetic research uses case-control status as the target trait. It is undetermined if autistic symptom domain severity underlying this heterogeneity is heritable and pleiotropic with other psychiatric and behavior traits in the same manner as autism case-control status. In N = 6064 autistic children in the SPARK cohort, we investigated the common genetic properties of twelve subscales from three clinical autism instruments measuring autistic traits: the Social Communication Questionnaire (SCQ), the Repetitive Behavior Scale-Revised (RBS-R), and the Developmental Coordination Disorder Questionnaire (DCDQ). Educational attainment polygenic scores (PGS) were significantly negatively correlated with eleven subscales, while AD

SUBMITTER: Thomas TR 

PROVIDER: S-EPMC9192633 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature