PET imaging of an optimized anti-PD-L1 probe ⁶⁸Ga-NODAGA-BMS986192 in immunocompetent mice and non-human primates.

ABSTRACT:

Background

Adnectin is a protein family derived from the 10th type III domain of human fibronectin (¹⁰Fn3) with high-affinity targeting capabilities. Positron emission tomography (PET) probes derived from anti-programmed death ligand-1 (PD-L1) Adnectins, including ¹⁸F- and ⁶⁸Ga-labeled BMS-986192, are recently developed for the prediction of patient response to immune checkpoint blockade. The ⁶⁸Ga-labeled BMS-986192, in particular, is an attractive probe for under-developed regions due to the broader availability of ⁶⁸Ga. However, the pharmacokinetics and biocompatibility of ⁶⁸Ga-labeled BMS-986192 are still unknown, especially in non-human primates, impeding its further clinical translation.

Methods

We develo

SUBMITTER: Zhou H 

PROVIDER: S-EPMC9192916 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature