Initial Immunomodulation and Outcome of Children with Multisystem Inflammatory Syndrome Related to COVID-19: A Multisite Study from India.

ABSTRACT:

Objective

To determine the outcomes in children with MIS-C receiving different immunomodulatory treatment.

Methods

In this multicentric, retrospective cohort study, data regarding treatment and outcomes of children meeting the WHO case definition for MIS-C, were collected. The primary composite outcome was the requirement of vasoactive/inotropic support on day 2 or beyond or need of mechanical ventilation on day 2 or beyond after initiation of immunomodulatory treatment or death during hospitalization in the treatment groups. Logistic regression and propensity score matching analyses were used to compare the outcomes in different treatment arms based on the initial immunomodulation, i.e., IVIG alone, IVIG plus steroids, and steroids alone.

Results

The data of 368 chil

SUBMITTER: Bagri NK 

PROVIDER: S-EPMC9192925 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature