A Review of Population Pharmacokinetic Analyses of Linezolid.

ABSTRACT: In recent years, many studies on population pharmacokinetics of linezolid have been conducted. This comprehensive review aimed to summarize population pharmacokinetic models of linezolid, by focusing on dosage optimization to maximize the probability of attaining a certain pharmacokinetic-pharmacodynamic parameter in special populations. We searched the PubMed and EMBASE databases for population pharmacokinetic analyses of linezolid using a parametric non-linear mixed-effect approach, including both observational and prospective trials. Of the 32 studies, 26 were performed in adults, four in children, and one in both adults and children. High between-subject variability was determined in the majority of the models, which was in line with the variability of linezolid concentrations previous

SUBMITTER: Bandin-Vilar E 

PROVIDER: S-EPMC9192929 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature