Neurocircuit dynamics of arbitration between decision-making strategies across obsessive-compulsive and related disorders.

ABSTRACT: Obsessions and compulsions are central components of obsessive-compulsive disorder (OCD) and obsessive-compulsive related disorders such as body dysmorphic disorder (BDD). Compulsive behaviours may result from an imbalance of habitual and goal-directed decision-making strategies. The relationship between these symptoms and the neural circuitry underlying habitual and goal-directed decision-making, and the arbitration between these strategies, remains unknown. This study examined resting state effective connectivity between nodes of these systems in two cohorts with obsessions and compulsions, each compared with their own corresponding healthy controls: OCD (n_OCD = 43; n_healthy = 24) and BDD (n_BDD = 21; n_healthy = 16). In individuals with OCD, the

SUBMITTER: Seok D 

PROVIDER: S-EPMC9192960 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature