Posterior-prefrontal and medial orbitofrontal regions play crucial roles in happiness and sadness recognition.

ABSTRACT: The core brain regions responsible for basic human emotions are not yet fully understood. We investigated the key areas responsible for emotion recognition of facial expressions of happiness and sadness using data obtained from patients who underwent local brain resection. A total of 44 patients with right cerebral hemispheric brain tumors and 33 healthy volunteers were enrolled and subjected to a facial expression recognition test. Voxel-based lesion-symptom mapping was performed to investigate the relationship between the accuracy of emotion recognition and the resected regions. Consequently, trade-off relationships were discovered: the posterior-prefrontal region was related to a low score of happiness recognition and a high score of sadness recognition (disorder-of-happiness group), wh

SUBMITTER: Nakajima R 

PROVIDER: S-EPMC9192961 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature