Dataset Information

Association of familial Mediterranean fever and epicardial adipose tissue: A systematic review and meta-analysis.

ABSTRACT:

Background and aim

Some studies reported a positive link between familial Mediterranean fever (FMF) and epicardial adipose tissue. Our meta-analysis aimed to evaluate whether there is a significant association between FMF and increased epicardial adipose tissue thickness.

Methods

We searched the following databases: PUBMED, WOS, OVID, SCOPUS, and EMBASE. Inclusion criteria were any original articles that reported epicardial adipose tissue in FMF patients with no age restriction, excluding reviews, case reports, editorials, animal studies, and non-English studies. Thirty eligible studies were screened full text but only five studies were suitable. We used RevMan software (5.4) for the meta-analysis.

Results

The total number of patients included in the meta-analysis in the FMF patients group is 256 (mean age = 24.3), and the total number in the control group is 188 (mean age = 24.98). The pooled analysis between FMF patients and controls was [mean difference = 0.82 (95% CI = 0.25-1.39), p-value = 0.005]. We observed heterogeneity that was not solved by random effects (p > 0.00001). We performed leave one out test by removing the Kozan et al. study, and the heterogeneity was solved (p = 0.07), and the results were (MD = 0.98, 95% CI = 0.52-1.43, p-value < 0.0001).

Conclusion

FMF patients are at increased risk of developing epicardial adipose tissue compared to controls. More multicenter studies with higher sample sizes are needed to support our results.

SUBMITTER: Motawea KR

PROVIDER: S-EPMC9193962 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Publications

Association of familial Mediterranean fever and epicardial adipose tissue: A systematic review and meta-analysis.

Motawea Karam R KR Kandil Omneya A OA Varney Joseph J Aboelenein Merna M Ibrahim Nancy N Shaheen Ahmed A Khairy Lina T LT Bakkour Agyad A Muwaili Ali H H AHH Muwaili Dhuha H H DHH Abdelmajid Fatima A A FAA Ahmad Eman M S EMS Albuni Mhd K MK Battikh Elias E Sawaf Bisher B Swed Sarya S Ahmed Safaa M A SMA Awad Dina M DM Shah Jaffer J Aiash Hani H

Health science reports 20220613 4

<h4>Background and aim</h4>Some studies reported a positive link between familial Mediterranean fever (FMF) and epicardial adipose tissue. Our meta-analysis aimed to evaluate whether there is a significant association between FMF and increased epicardial adipose tissue thickness.<h4>Methods</h4>We searched the following databases: PUBMED, WOS, OVID, SCOPUS, and EMBASE. Inclusion criteria were any original articles that reported epicardial adipose tissue in FMF patients with no age restriction, e ...[more]

PMID: 35734339

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Project description:BackgroundAtherosclerosis is now widely recognized as a multifactorial disease with outcomes that arise from complex factors such as plaque components, blood flow, and inflammation. Epicardial adipose tissue (EAT) is a metabolically active fat depot, abundant in proinflammatory cytokines, and has been correlated with the extent and severity of carotid artery disease (CD). The locations most frequently affected by carotid atherosclerosis are the proximal internal carotid artery (ie, the origin) and the common carotid artery bifurcation. Progression of atheromatous plaque at the carotid bifurcation results in luminal narrowing, often accompanied by ulceration. However, there are no systematic analyses or well-conducted meta-analyses to evaluate the relationship between EAT and CD. The aim of this study is to examine this association of EAT with CD in different ages and sex.MethodsThis systematic review and meta-analysis will be conducted using published studies that will be identified from electronic databases (ie, PubMed, EMBASE, Web of Science, and Google Scholar. Studies that (1) examined the association between EAT and CD, (2) focus on cohort, case-control and cross-sectional studies, (3) will conducted among in adults aged 40 to 70 years, (4) provided sufficient data for calculating ORs or relative risk with a 95% CI, (5) will published as original articles written in English or other languages, and (6) have been published until January 2018 will be included. Study selection, data collection, quality assessment and statistical syntheses will be conducted based on discussions among investigators.ResultsWe propose the current protocol to evaluate the evaluation of EAT with ED.ConclusionThis systematic review will not need ethical approval, because it does not involve human beings. The results and findings of this study will be submitted and published in a scientific peer-reviewed journal.Ethics and disseminationEthics approval was not required for this study because it was based on published studies. The results and findings of this study will be submitted and published in a scientific peer-reviewed journal.Trial registration numberPROSPERO (CRD42018083458).

Dataset Information

Association of familial Mediterranean fever and epicardial adipose tissue: A systematic review and meta-analysis.

Background and aim

Methods

Results

Conclusion

Publications

Association of familial Mediterranean fever and epicardial adipose tissue: A systematic review and meta-analysis.

Similar Datasets

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