DNA methylation dynamics associated with long-term isolation of simulated space travel.

ABSTRACT: Long-term isolation is one of the risk factors that astronauts will encounter in spaceflight. At present, few researches have explored DNA methylation dynamics during long-term isolation. In this study, using time series DNA methylation data from "Mars-500" mission, we conducted a multi-step analysis to investigate the characteristics and dynamic patterns of DNA methylation as well as their functional insights during long-term isolation. The results showed that genome-wide methylation changes were minimal. In the six identified DNA methylation dynamic patterns, most of significantly fluctuating CpG sites could be returned to the baseline in post-isolation, and the remaining sites persistently decreased during isolation. Next, functional enrichment analysis of genes with each pattern reveal

SUBMITTER: Hou F 

PROVIDER: S-EPMC9194130 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature