Early-Life Exposure to Malnutrition From the Chinese Famine on Risk of Asthma and Chronic Obstructive Pulmonary Disease in Adulthood.

ABSTRACT:

Objectives

Intrauterine malnutrition has a long-term effect on respiratory and lung function. However, few studies have explored the association between early-life exposure to famine with asthma and chronic obstructive pulmonary disease (COPD) in adulthood. Therefore, we aimed to investigate the association of early-life exposure to the Chinese famine of 1959-1962 with asthma and COPD later in life.

Methods

This national population-based study included 6,771 participants from the baseline survey of the China Health and Retirement Longitudinal Study (CHARLS) who were born around the time of the Chinese famine. The famine exposure groups were determined according to the participants' birth year as non-exposed (1964-1967), fetal-exposed (1959-1962), preschool-exposed (1954-1957

SUBMITTER: Jin C 

PROVIDER: S-EPMC9194571 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature