Altered innate immune profile in blood of systemic mastocytosis patients.

ABSTRACT:

Background

Mast cells (MC) from systemic mastocytosis (SM) patients release MC mediators that lead to an altered microenvironment with potential consequences on innate immune cells, such as monocytes and dendritic cells (DC). Here we investigated the distribution and functional behaviour of different populations of blood monocytes and DC among distinct diagnostic subtypes of SM.

Methods

Overall, we studied 115 SM patients - 45 bone marrow mastocytosis (BMM), 61 indolent SM (ISM), 9 aggressive SM (ASM)- and 32 healthy donors (HD). Spontaneous and in vitro-stimulated cytokine production by blood monocytes, and their plasma levels, together with the distribution of different subsets of blood monocytes and DCs, were investigated.

Results

SM patients showed increase

SUBMITTER: Perez-Pons A 

PROVIDER: S-EPMC9194602 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature