Long-term Risk of Overdose or Mental Health Crisis After Opioid Dose Tapering.

ABSTRACT:

Importance

Patients prescribed long-term opioid therapy are increasingly undergoing dose tapering. Recent studies suggest that tapering is associated with short-term risks of substance misuse, overdose, and mental health crisis, although lower opioid dose could reduce risks of adverse events over the longer term.

Objective

To assess the longer-term risks of overdose or mental health crisis associated with opioid dose tapering.

Design, setting, and participants

This is a cohort study using an exposure-crossover analysis. Data were obtained from the OptumLabs Data Warehouse, which includes deidentified medical and pharmacy claims and enrollment records for commercial insurance and Medicare Advantage enrollees, representing a diverse mixture of ages, races, ethnicities,

SUBMITTER: Fenton JJ 

PROVIDER: S-EPMC9194670 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature