Outcomes After Endovascular Thrombectomy With or Without Alteplase in Routine Clinical Practice.

ABSTRACT:

Importance

The effectiveness and safety of intravenous alteplase given before or concurrently with endovascular thrombectomy (EVT) is uncertain. Randomized clinical trials suggest there is little difference in outcomes but with only modest precision and insufficient power to analyze uncommon outcomes including symptomatic intracranial hemorrhage (sICH).

Objective

To determine whether 8 prespecified outcomes are different in patients with acute ischemic stroke treated in routine clinical practice with EVT with alteplase compared with patients treated with EVT alone without alteplase. It was hypothesized that alteplase would be associated with higher risk of sICH.

Design, setting, and participants

This was an observational cohort study conducted from February 1, 2019, t

SUBMITTER: Smith EE 

PROVIDER: S-EPMC9194745 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature