Expression and Secretion of Circular RNAs in the Parasitic Nematode, Ascaris suum.

ABSTRACT: Circular RNAs (circRNAs) are a recently identified RNA species with emerging functional roles as microRNA (miRNA) and protein sponges, regulators of gene transcription and translation, and modulators of fundamental biological processes including immunoregulation. Relevant to this study, circRNAs have recently been described in the parasitic nematode, Haemonchus contortus, suggesting they may have functionally important roles in parasites. Given their involvement in regulating biological processes, a better understanding of their role in parasites could be leveraged for future control efforts. Here, we report the use of next-generation sequencing to identify 1,997 distinct circRNAs expressed in adult female stages of the gastrointestinal parasitic nematode, Ascaris suum. We de

SUBMITTER: Minkler SJ 

PROVIDER: S-EPMC9194832 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature