Prolonged deprivation of arginine or leucine induces PI3K/Akt-dependent reactivation of mTORC1.

ABSTRACT: The mechanistic target of rapamycin complex 1 (mTORC1) is a serine/threonine kinase complex that promotes anabolic processes including protein, lipid, and nucleotide synthesis, while suppressing catabolic processes such as macroautophagy. mTORC1 activity is regulated by growth factors and amino acids which signal through distinct but integrated molecular pathways: growth factors largely signal through the PI3K/Akt-dependent pathway, whereas the availabilities of amino acids leucine and arginine are communicated to mTORC1 by the Rag-GTPase pathway. While it is relatively well described how acute changes in leucine and arginine levels affect mTORC1 signaling, the effects of prolonged amino acid deprivation remain less well understood. Here, we demonstrate that prolonged deprivation of argini

SUBMITTER: Buel GR 

PROVIDER: S-EPMC9194872 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature