Molecular investigations on Candida glabrata clinical isolates for pharmacological targeting.

ABSTRACT: Prevalence of drug resistant C. glabrata strains in hospitalized immune-compromised patients with invasive fungal infections has increased at an unexpected pace. This has greatly pushed researchers in identification of mutations/variations in clinical isolates for better assessment of the prevailing drug resistance trends and also for updating of antifungal therapy regime. In the present investigation, the clinical isolates of C. glabrata were comprehensively characterized at a molecular level using metabolic profiling and transcriptional expression analysis approaches in combination with biochemical, morphological and chemical profiling methods. Biochemically, significant variations in azole susceptibility, surface hydrophobicity, and oxidative stress generation were observe

SUBMITTER: Gupta H 

PROVIDER: S-EPMC9194923 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature