Cell migration orchestrates migrasome formation by shaping retraction fibers.

ABSTRACT: Migrasomes are recently discovered vesicle-like structures on retraction fibers of migrating cells that have been linked with transfer of cellular contents, shedding of unwanted materials, and information integration. However, whether and how the cell migration paradigm regulates migrasome formation is not clear. Here, we report that there are significantly fewer migrasomes in turning cells compared with straight persistently migrating cells. The major insight underlying this observation is that as the cells elongate, their rear ends become narrower, subsequently resulting in fewer retraction fibers during impersistent migration. In addition to migration persistence, we reveal that migration speed positively corelates with migrasome formation, owing to the derived length of retraction fibe

SUBMITTER: Fan C 

PROVIDER: S-EPMC9195050 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature