Identification of ER/SR resident proteins as biomarkers for ER/SR calcium depletion in skeletal muscle cells.

ABSTRACT:

Background

Aberrations to endoplasmic/sarcoplasmic reticulum (ER/SR) calcium concentration can result in the departure of endogenous proteins in a phenomenon termed exodosis. Redistribution of the ER/SR proteome can have deleterious effects to cell function and cell viability, often contributing to disease pathogenesis. Many proteins prone to exodosis reside in the ER/SR via an ER retention/retrieval sequence (ERS) and are involved in protein folding, protein modification, and protein trafficking. While the consequences of their extracellular presence have yet to be fully delineated, the proteins that have undergone exodosis may be useful for biomarker development. Skeletal muscle cells rely upon tightly coordinated ER/SR calcium release for muscle contractions, and perturbations t

SUBMITTER: Greer LK 

PROVIDER: S-EPMC9195201 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature