Mobility test to assess functional vision in dark-adapted patients with Leber congenital amaurosis.

ABSTRACT:

Background

Inherited retinal degenerations (IRDs) affect daylight and night vision to different degrees. In the current work, we devise a method to quantify mobility under dark-adapted conditions in patients with severe childhood blindness due to Leber congenital amaurosis (LCA). Mobility thresholds from two different LCA genotypes are compared to dark-adapted vision measurements using the full-field stimulus test (FST), a conventional desktop outcome measure of rod vision.

Methods

A device consisting of vertical LED strips on a plane resembling a beaded curtain was programmed to produce a rectangular pattern target defining a 'door' of varying luminance that could appear at one of three positions. Mobility performance was evaluated by letting the subject walk from a fixed s

SUBMITTER: Roman AJ 

PROVIDER: S-EPMC9195222 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature