Neurobiological mechanisms of early life adversity, blunted stress reactivity and risk for addiction.

ABSTRACT: Blunted stress reactivity resulting from early exposure to stress during childhood and adolescence may increase vulnerability to addiction. Early life adversity (ELA) affects brain structure and function and results in blunted stress axis reactivity. In this review, we focus on the underlying neurobiological mechanisms associated with a blunted response to stress, ELA, and risk for addictive disorders. ELA and blunted reactivity are accompanied by unstable mood regulation, impulsive behaviors, and reduced cognitive function. Neuroimaging studies reveal cortical and subcortical changes in persons exposed to ELA and those who have a genetic disposition for addiction. We propose a model in which blunted stress reactivity may be a marker of risk for addiction through an altered motivational an

SUBMITTER: al'Absi M 

PROVIDER: S-EPMC9195251 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature