GenErode: a bioinformatics pipeline to investigate genome erosion in endangered and extinct species.

ABSTRACT:

Background

Many wild species have suffered drastic population size declines over the past centuries, which have led to 'genomic erosion' processes characterized by reduced genetic diversity, increased inbreeding, and accumulation of harmful mutations. Yet, genomic erosion estimates of modern-day populations often lack concordance with dwindling population sizes and conservation status of threatened species. One way to directly quantify the genomic consequences of population declines is to compare genome-wide data from pre-decline museum samples and modern samples. However, doing so requires computational data processing and analysis tools specifically adapted to comparative analyses of degraded, ancient or historical, DNA data with modern DNA data as well as personnel trained to pe

SUBMITTER: Kutschera VE 

PROVIDER: S-EPMC9195343 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature