Mendelian randomization analysis of 37 clinical factors and coronary artery disease in East Asian and European populations.

ABSTRACT:

Background

Coronary artery disease (CAD) remains the leading cause of mortality worldwide despite enormous efforts devoted to its prevention and treatment. While many genetic loci have been identified to associate with CAD, the intermediate causal risk factors and etiology have not been fully understood. This study assesses the causal effects of 37 heritable clinical factors on CAD in East Asian and European populations.

Methods

We collected genome-wide association summary statistics of 37 clinical factors from the Biobank Japan (42,793 to 191,764 participants) and the UK Biobank (314,658 to 442,817 participants), paired with summary statistics of CAD from East Asians (29,319 cases and 183,134 controls) and Europeans (91,753 cases and 311,344 controls). These clinical factor

SUBMITTER: Wang K 

PROVIDER: S-EPMC9195360 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature