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A map of bat virus receptors derived from single-cell multiomics.

ABSTRACT: Bats are considered reservoirs of many lethal zoonotic viruses and have been implicated in several outbreaks of emerging infectious diseases, such as SARS-CoV, MERS-CoV, and SARS-CoV-2. It is necessary to systematically derive the expression patterns of bat virus receptors and their regulatory features for future research into bat-borne viruses and the prediction and prevention of pandemics. Here, we performed single-nucleus RNA sequencing (snRNA-seq) and single-nucleus assay for transposase-accessible chromatin using sequencing (snATAC-seq) of major organ samples collected from Chinese horseshoe bats (Rhinolophus affinis) and systematically checked the expression pattern of bat-related virus receptors and chromatin accessibility across organs and cell types, providing a valuable dataset for studying the nature of infection among bat-borne viruses.

SUBMITTER: Lv T

PROVIDER: S-EPMC9195401 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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A map of bat virus receptors derived from single-cell multiomics.

Lv Tianhang T Wang Xiaoshan X Yu Chao C Wang Zhifeng Z Xiang Rong R Li Linmiao L Yuan Yue Y Wang Yuhang Y Wei Xiaoyu X Yu Yeya Y He Xiangyang X Zhang Libiao L Deng Qiuting Q Wu Peiying P Hou Yong Y Chen Jinping J Liu Chuanyu C Wong Gary G Liu Longqi L

Scientific data 20220614 1

Bats are considered reservoirs of many lethal zoonotic viruses and have been implicated in several outbreaks of emerging infectious diseases, such as SARS-CoV, MERS-CoV, and SARS-CoV-2. It is necessary to systematically derive the expression patterns of bat virus receptors and their regulatory features for future research into bat-borne viruses and the prediction and prevention of pandemics. Here, we performed single-nucleus RNA sequencing (snRNA-seq) and single-nucleus assay for transposase-acc ...[more]

PMID: 35701476

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