The association of COVID-19 severity and susceptibility and genetic risk factors: A systematic review of the literature.

ABSTRACT:

Background

COVID-19 is associated with several risk factors such as distinct ethnicities (genetic ancestry), races, sexes, age, pre-existing comorbidities, smoking, and genetics. The authors aim to evaluate the correlation between variability in the host genetics and the severity and susceptibility towards COVID-19 in this study.

Methods

Following the PRISMA guidelines, we retrieved all the relevant articles published until September 15, 2021, from two online databases: PubMed and Scopus.

Findings

High-risk HLA haplotypes, higher expression of ACE polymorphisms, and several genes of cellular proteases such as TMPRSS2, FURIN, TLL-1 increase the risk of susceptibility and severity of COVID-19. In addition, upregulation of several genes encoding for both innate and acqui

SUBMITTER: Ishak A 

PROVIDER: S-EPMC9195407 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature