Network pharmacology and molecular docking approach to elucidate the mechanisms of Liuwei Dihuang pill in diabetic osteoporosis.

ABSTRACT:

Background

Diabetic osteoporosis (DOP) is one of the chronic complications of diabetes mellitus, but without a standardized treatment plan till now. Liuwei Dihuang pill (LDP) has gradually exerted a remarkable effect on DOP in recent years; its specific mechanism is not clear yet.

Methods

We adopted network pharmacology approaches, including multi-database search, pharmacokinetic screening, network construction analysis, gene ontology enrichment analysis, Kyoto Encyclopedia of Genes and Genomes pathway analysis and molecular docking to elaborate the active components, signaling pathways and potential mechanisms of LDP in the treatment of DOP.

Results

Twenty-seven active ingredients and 55 related disease targets have been found through integrated network pharmacology.

SUBMITTER: Lu Z 

PROVIDER: S-EPMC9195436 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature