The Role of CD4⁺CD8⁺ T Cells in HIV Infection With Tuberculosis.

ABSTRACT:

Background

Tuberculosis (TB) is an important opportunistic infection in acquired immunodeficiency diseases (AIDS). Although the frequency of CD4⁺CD8⁺ double-positive (DP) T cells has been observed to increase in pathological conditions, their role (phenotypic and functional) is poorly described, especially in human immunodeficiency virus (HIV) infection with TB (HIV/TB (HT) coinfection).

Methods

The percentage and phenotypic and functional properties of peripheral blood DP T cells in patients with HT coinfection in comparison to uninfected controls and to patients with HIV or TB mono-infection were analyzed by direct intracellular cytokine staining (ICS).

Results

Total and CD4^lowCD8^high DP T cells were significantly increase

SUBMITTER: Zou S 

PROVIDER: S-EPMC9195591 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature