Genomic Analysis of SARS-CoV-2 Variants of Concern Circulating in Hawai'i to Facilitate Public-Health Policies.

ABSTRACT: Using genomics, bioinformatics and statistics, herein we demonstrate the effect of statewide and nationwide quarantine on the introduction of SARS-CoV-2 variants of concern (VOC) in Hawai'i. To define the origins of introduced VOC, we analyzed 260 VOC sequences from Hawai'i, and 301,646 VOC sequences worldwide, deposited in the GenBank and global initiative on sharing all influenza data (GISAID), and constructed phylogenetic trees. The trees define the most recent common ancestor as the origin. Further, the multiple sequence alignment used to generate the phylogenetic trees identified the consensus single nucleotide polymorphisms in the VOC genomes. These consensus sequences allow for VOC comparison and identification of mutations of interest in relation to viral immune evasion and host im

SUBMITTER: Maison DP 

PROVIDER: S-EPMC9196110 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature