Differential Regulation of Allergic Airway Inflammation by Acetylcholine.

ABSTRACT: Acetylcholine (ACh) from neuronal and non-neuronal sources plays an important role in the regulation of immune responses and is associated with the development of several disease pathologies. We have previously demonstrated that group 2 innate lymphoid cell (ILC2)-derived ACh is required for optimal type 2 responses to parasitic infection and therefore sought to determine whether this also plays a role in allergic inflammation. Rora ^Cre+ Chat ^LoxP mice (in which ILC2s cannot synthesize ACh) were exposed to an allergenic extract of the fungus Alternaria alternata, and immune responses in the airways and lung tissues were analyzed. Airway neutrophilia and expression of the neutrophil chemoattractants CXCL1 and CXCL2 were enhanced 24 h after exposure

SUBMITTER: Roberts LB 

PROVIDER: S-EPMC9196131 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature