Brain activation during emotion regulation in women with premenstrual dysphoric disorder.

ABSTRACT:

Background

Difficulties in regulating emotions are linked to the core symptoms of premenstrual dysphoric disorder (PMDD). We therefore investigated the neural substrates of emotion-regulation problems in women with PMDD.

Methods

On the basis of self-evaluations over 2 months on the Daily Record of Severity of Problems, eligible participants were assigned to two groups: PMDD and control (18 per group). Functional magnetic resonance imaging (fMRI) and a well-validated task were used to assess brain function during emotion regulation. Participants were tested twice, once during the follicular (asymptomatic) and once in the late luteal (symptomatic) phase of the menstrual cycle.

Results

Women with PMDD gave higher ratings of negative affect in the luteal phase than in the

SUBMITTER: Petersen N 

PROVIDER: S-EPMC9196139 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature