Association between medication adherence and disease outcomes in patients with hepatitis B-related cirrhosis: a population-based case-control study.

ABSTRACT:

Objective

To evaluate medication adherence among patients with hepatitis B-related cirrhosis who developed decompensation and mortality, and to examine the association between medication adherence and patients' disease outcomes.

Design

In this retrospective case-control study, patients aged over 20 years old and diagnosed with both chronic hepatitis B and cirrhosis from 2007 to 2016 are identified using a population-based medical claims database. Two prognosis endpoints (decompensation and mortality) are used, respectively, to classify subjects into two different case-control sets. Study groups are propensity-score matched. Medication possession ratio (MPR) is used as a measure of treatment adherence for oral antiviral drugs, and conditional logistic regression models are us

SUBMITTER: Fu KY 

PROVIDER: S-EPMC9196175 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature