Patient-specific fluid-structure simulations of anomalous aortic origin of right coronary arteries.

ABSTRACT:

Objectives

Anomalous aortic origin of the right coronary artery (AAORCA) may cause ischemia and sudden death. However, the specific anatomic indications for surgery are unclear, so dobutamine-stress instantaneous wave-free ratio (iFR) is increasingly used. Meanwhile, advances in fluid-structure interaction (FSI) modeling can simulate the pulsatile hemodynamics and tissue deformation. We sought to evaluate the feasibility of simulating the resting and dobutamine-stress iFR in AAORCA using patient-specific FSI models and to visualize the mechanism of ischemia within the intramural geometry and associated lumen narrowing.

Methods

We developed 6 patient-specific FSI models of AAORCA using SimVascular software. Three-dimensional geometries were segmented from coronary computed to

SUBMITTER: Jiang MX 

PROVIDER: S-EPMC9196314 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature