Informative presence bias in analyses of electronic health records-derived data: a cautionary note.

ABSTRACT:

Objective

Electronic health record (EHR)-derived data are extensively used in health research. However, the pattern of patient interaction with the healthcare system can result in informative presence bias if those who have poorer health have more data recorded than healthier patients. We aimed to determine how informative presence affects bias across multiple scenarios informed by real-world healthcare utilization patterns.

Materials and methods

We conducted an analysis of EHR data from a pediatric healthcare system as well as simulation studies to characterize conditions under which informative presence bias is likely to occur. This analysis extends prior work by examining a variety of scenarios for the relationship between a biomarker and a health event of interest and th

SUBMITTER: Harton J 

PROVIDER: S-EPMC9196698 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature