<i>In vitro</i> Inhibition of HIV-1 by Cyclotide-Enriched Extracts of <i>Viola tricolor</i>.

ABSTRACT: Since viral infectious diseases continue to be a global health threat, new antiviral drugs are urgently needed. A unique class of therapeutic compounds are antimicrobial peptides (AMPs). They can be found in humans, bacteria and plants. Plants express a wide variety of such defense peptides as part of their innate immune system to protect from invading pathogens. Cyclotides are non-classical AMPs that share a similar structure. Their unique topology consists of a circular peptide backbone and disulfide bonds. In previous studies they have been attributed to a wide range of biological activities. To identify novel cyclotides with antiviral activity, we established a library of plant extracts largely consisting of cyclotide-rich species and screened them as inhibitors of HIV-1 infection. Sub

SUBMITTER: Conzelmann C 

PROVIDER: S-EPMC9196940 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature