The Chemerin-CMKLR1 Axis is Functionally important for Central Regulation of Energy Homeostasis.

ABSTRACT: Chemerin is an adipokine involved in inflammation, adipogenesis, angiogenesis and energy metabolism, and has been hypothesized as a link between obesity and type II diabetes. In humans affected by obesity, chemerin gene expression in peripheral tissues and circulating levels are elevated. In mice, plasma levels of chemerin are upregulated by high-fat feeding and gain and loss of function studies show an association of chemerin with body weight, food intake and glucose homeostasis. Therefore, chemerin is an important blood-borne mediator that, amongst its other functions, controls appetite and body weight. Almost all studies of chemerin to date have focused on its release from adipose tissue and its effects on peripheral tissues with the central effects largely overlooked. To demonstrate a

SUBMITTER: Yun H 

PROVIDER: S-EPMC9196942 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature