Pulmonary drug delivery and retention: A computational study to identify plausible parameters based on a coupled airway-mucus flow model.

ABSTRACT: Pulmonary drug delivery systems rely on inhalation of drug-laden aerosols produced from aerosol generators such as inhalers, nebulizers etc. On deposition, the drug molecules diffuse in the mucus layer and are also subjected to mucociliary advection which transports the drugs away from the initial deposition site. The availability of the drug at a particular region of the lung is, thus, determined by a balance between these two phenomena. A mathematical analysis of drug deposition and retention in the lungs is developed through a coupled mathematical model of aerosol transport in air as well as drug molecule transport in the mucus layer. The mathematical model is solved computationally to identify suitable conditions for the transport of drug-laden aerosols to the deep lungs. This study id

SUBMITTER: Chakravarty A 

PROVIDER: S-EPMC9197018 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature