Long-Term Kidney Prognosis and Pathological Characteristics of Late-Onset Lupus Nephritis.

ABSTRACT:

Background

Arguments still exist on prognosis of late-onset SLE, especially their kidney function. The purpose of this study was to investigate long-term kidney outcomes in patients with late-onset lupus nephritis (LN).

Methods

A retrospective long-term cohort study was conducted in adult Chinese patients with LN. The patients were divided into late- (>50 years) and early-onset (<50 years) LN groups. The baseline characteristics, especially the kidney pathological characteristics, were compared. The cohort was followed-up for kidney outcome defined as doubling of serum creatinine or ESRD. Cox regression analysis was used to examine the association between late onset LN and its outcomes.

Results

A total of 1,264 patients were recruited, who were assigned to late-onset

SUBMITTER: Tian N 

PROVIDER: S-EPMC9197116 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature