Chaperone-mediated autophagy degrades Keap1 and promotes Nrf2-mediated antioxidative response.

ABSTRACT: Accumulation of oxidative stress is highly intertwined with aging process and contributes to aging-related diseases, such as neurodegenerative diseases. Deciphering the molecular machinery that regulates oxidative stress is fundamental to further uncovering the pathogenesis of these diseases. Chaperone-mediated autophagy (CMA), a highly selective lysosome-dependent degradation process, has been proven to be an important maintainer of cellular homeostasis through multiple mechanisms, one of which is the attenuation of oxidative stress. However, the specific mechanisms underlying this antioxidative action of CMA are not fully understood. In this study, we found that CMA directly degrades Kelch-like ECH-associated protein 1 (Keap1), an adaptor of E3 ligase complex that promotes the degradatio

SUBMITTER: Zhu L 

PROVIDER: S-EPMC9197408 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature