Distinct Roles of Classical and Lectin Pathways of Complement in Preeclamptic Placentae.

ABSTRACT: Pre-eclampsia is a pregnancy complication characterized by defective vascular remodeling in maternal decidua responsible for reduced blood flow leading to functional and structural alterations in the placenta. We have investigated the contribution of the complement system to decidual vascular changes and showed that trophoblasts surrounding unremodeled vessels prevalent in preeclamptic decidua fail to express C1q that are clearly detected in cells around remodeled vessels predominant in control placenta. The critical role of C1q is supported by the finding that decidual trophoblasts of female C1qa^-/- pregnant mice mated to C1qa^+/+ male mice surrounding remodeled vessels express C1q of paternal origin. Unlike C1qa^-/- pregnant mice, heter

SUBMITTER: Belmonte B 

PROVIDER: S-EPMC9197446 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature