The Multifaceted Actions of CD73 During Development and Suppressive Actions of Regulatory T Cells.

ABSTRACT: Adenosine (Ado) has been shown to have immunosuppressive effects in a variety of diseases. It can either be released directly into the extracellular environment by cells, or it can be produced by degradation of ATP within the extracellular spaces. This extracellular pathway is facilitated by the concerted actions of the ectoenzymes CD39 and CD73. In a first step CD39 dephosphorylates ATP to ADP and AMP, respectively, and in a second step CD73 converts AMP to Ado. Thus, activity of CD73 on the cell surface of cells is the rate limiting step in the generation of extracellular Ado. Among T cells, CD73 is most abundantly expressed by regulatory T cells (Tregs) and is even upregulated after their activation. Functionally, the generation of Ado by CD73⁺ Tregs has been shown to play a

SUBMITTER: Da M 

PROVIDER: S-EPMC9197450 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature