High-affinity autoreactive plasma cells disseminate through multiple organs in patients with immune thrombocytopenic purpura.

ABSTRACT: The major therapeutic goal for immune thrombocytopenic purpura (ITP) is to restore normal platelet counts using drugs to promote platelet production or by interfering with mechanisms responsible for platelet destruction. Eighty percent of patients with ITP possess anti-integrin αIIbβ3 IgG autoantibodies that cause platelet opsonization and phagocytosis. The spleen is considered the primary site of autoantibody production by autoreactive B cells and platelet destruction. The immediate failure in approximately 50% of patients to recover a normal platelet count after anti-CD20 rituximab-mediated B cell depletion and splenectomy suggests that autoreactive, rituximab-resistant, IgG-secreting B cells (IgG-SCs) reside in other anatomical compartments. We analyzed more than 3,300 single IgG-SCs fr

SUBMITTER: Canales-Herrerias P 

PROVIDER: S-EPMC9197514 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature