Characterization of the Role of Integrin α5β1 in Platelet Function, Hemostasis, and Experimental Thrombosis.

ABSTRACT:

Objective

 Integrins are key regulators of various platelet functions. The pathophysiological importance of most platelet integrins has been investigated, with the exception of α5β1, a receptor for fibronectin. The aim of this study was to characterize the role of α5β1 in megakaryopoiesis, platelet function, and to determine its importance in hemostasis and arterial thrombosis.

Approach and results

 We generated a mouse strain deficient for integrin α5β1 on megakaryocytes and platelets (PF4Cre-α5^-/-). PF4Cre-α5^-/- mice were viable, fertile, and presented no apparent signs of abnormality. Megakaryopoiesis appears unaltered as evidence by a normal megakaryocyte morphology and development, which is in agreement with a normal platelet count. Expression of t

SUBMITTER: Janus-Bell E 

PROVIDER: S-EPMC9197593 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature