Abbreviated MDS-UPDRS for Remote Monitoring in PD Identified Using Exhaustive Computational Search.

ABSTRACT:

Background

The Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) comprises 50 items, consisting of historical questions and motor ratings, typically taking around 30 minutes to complete. We sought to identify an abbreviated version that could facilitate use in clinical practice or used remotely via telemedicine.

Methods

To create an 8-item version we conducted an "exhaustive search" of all possible subsets. We measured explained variance in comparison to the 50-item version using linear regression, with the "optimal" subset maximising this while also meeting remote assessment practicality constraints. The subset was identified using a dataset collected by the Parkinson's Progression Markers Initiative and validated using an MDS Non-Motor Symptoms

SUBMITTER: Morinan G 

PROVIDER: S-EPMC9197633 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature